Abstract Covalent drugs can achieve high potency with long dosing intervals. However. concerns remain about side-effects associated with off-target reactivity. Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding. https://www.chiggate.com/mitski-be-the-cowboy-lp-coke-bottle-clear-on-sale/