Background: KP-1461 is a prodrug to KP-1212. KP-1212 is a viral mutagen designed to increase viral error rate. Methods: We describe 2 phase I studies: KP1461-101 (double-blind. placebo-controlled. https://www.kingarte.com/product-category/food-servicecommercial-kitchen-equipmentcooking-equipmentcommercial-ovensconvection-ovens/